![]() ![]() ![]() Furthermore, the heat-transfer in continuous flow installations is several orders of magnitude greater then what is usually observed for traditional batch process vessels. Recently, we have transformed a diazomethane batch process into a continuous flow process, which enables us to supply the growing demand of at least 500 tons/year of a specific product.Ĭompared to batch chemistry, the reaction volumes in flow chemistry are much lower and inherently represent a lower safety risk upon the unlikely event of a runaway reaction. At Ajinomoto Bio-Pharma Services, we have a long-standing successful track record of assisting customers with their hazardous chemistry needs. ![]() The enhanced safety of chemical processes is often the driving force to switch from batch to flow processing. In the future, a strong growth is anticipated for continuous flow manufacturing of active pharmaceutical ingredients as it offers a number of important advantages over traditional batch manufacturing in terms of quality, safety and sustainability of the overall process. 1 Moreover, with the release of the draft guidance “Quality Considerations for Continuous Manufacturing” in February 2019, the Food and Drug Administration (FDA) is determined to promote the implementation of continuous manufacturing processes with the main objective to improve product quality, which is the main underlying cause of drug shortages and recalls. In a recent survey questioning both CDMOs and major pharma companies, the majority anticipates that in the next 15 years, there will be a shift from batch to flow to up to 25% of the total portfolio. While batch process chemistry remains the standard in the pharmaceutical industry, a clear increase in continuous flow processes has emerged over the past decade thanks to the commercialization of preparative flow reactor units. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |